Antioxidant components of naturally-occurring oils exhibit marked anti ...
The upper respiratory tract functions to protect lower respiratory structures from chemical and biological agents in inspired air. Cellular oxidative stress leading to acute and chronic inflammation contributes to the resultant pathology in many of these exposures and is typical of allergic disease, chronic sinusitis, pollutant exposure, and bacterial and viral infections.Little is known about the effective means by which topical treatment of the nose can strengthen its antioxidant and anti-inflammatory defenses. The present study was undertaken to determine if naturally-occurring plant oils with reported antioxidant activity can provide mechanisms through which upper respiratory protection might occur.
Methods: Controlled exposure of the upper respiratory system to ozone and nasal biopsy were carried out in healthy human subjects to assess mitigation of the ozone-induced inflammatory response and to assess gene expression in the nasal mucosa induced by a mixture of five naturally-occurring antioxidant oils - aloe, coconut, orange, peppermint and vitamin E.
Cells of the BEAS-2B and NCI-H23 epithelial cell lines were used to investigate the source and potential intracellular mechanisms of action responsible for oil-induced anti-inflammatory activity.
Results: Aerosolized pretreatment with the mixed oil preparation significantly attenuated ozone-induced nasal inflammation. Although most oil components may reduce oxidant stress by undergoing reduction, orange oil was demonstrated to have the ability to induce long-lasting gene expression of several antioxidant enzymes linked to Nrf2, including HO-1, NQO1, GCLm and GCLc, and to mitigate the pro-inflammatory signaling of endotoxin in cell culture systems.
Nrf2 activation was demonstrated. Treatment with the aerosolized oil preparation increased baseline levels of nasal mucosal HO-1 expression in 9 of 12 subjects.
What Is The Respiratory Sysytem - News
Methods: Controlled exposure of the upper respiratory system to ozone and nasal biopsy were carried out in healthy human subjects to assess mitigation of the ozone-induced inflammatory response and to assess gene expression in the nasal mucosa induced
Designed in collaboration with respiratory therapists, the KimVent Multi-Access Port (MAP) Closed Suction System addresses requirements for VAP prevention best practices from the American Association for Respiratory Care (AARC) as the system maintains
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Veterans who have been deployed to combat areas, particularly Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn, should be aware of new and concerning respiratory system problems, including unexplained coughing,
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respiratory system: Definition from Answers.com
(Click to enlarge) respiratory system A. lung B. bronchial tubes C. nose D. mouth E. trachea F. diaphragm (Carlyn Iverson) respiratory system n
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This exchange of gases is the respiratory system's means of getting oxygen to the blood. ... What's This? You are viewing a page in The Franklin Institute's ...
Organization of Respiratory Sysytem
The lungs are the primary organs of the respiratory system. ... The pleural membrane surrounds the lung and is associated with the thoracic wall. ...
What affects the respiratory system
the things that affect the respiratory sysytem are things like asthma, Chronic ... The infection begins by reaching the pulmonary alveoli where the bacteria is ...
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